Galanthamine hydrobromide (Nivalin, Sopharma AD, Bulgaria) is an orally and parenterally active reversible cholinesterase inhibitor which increases postsynaptic membrane susceptibility to acetylcholine.

In 1956 in Sofia, the pharmacologist D. Paskov suggested and L. Ivanova extracted an alkaloid base from the leaves of the plant Galanthus nivalis L. that they named galanthamine. In the form of hydrobromide salt it is commercially available as a registered product under the trade name NIVALIN [1] Fig. 1.

Fig. 1 Structural formula of Galanthamine (Nivalin).

4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro-[3a,3,2,-ef][2]-benzazepin-6-ol